experimental design

Simulation-based empirical Bayes

Empirical Bayes (EB) performs simultaneous inference across many related latent variables. Classical EB assumes that the likelihood $p(x | z)$ is tractable. In many scientific applications, however, the likelihood is available only through a …

Reconstruction of δ$^{13}$ $C_{{DIC}}$ in the Atlantic Ocean: a probabilistic machine learning approach for filling historical data gaps

Optimizing the design of spatial genomics studies

Spatial genomic technologies characterize the relationship between the structural organization of cells and their cellular state. Despite the availability of various spatial transcriptomic and proteomic profiling platforms, these experiments remain …